The World Leader in Automated Sperm Quality Analyzers with over 3,500 Instruments Sold  

Company Products Support Distributors VideosStudiesContact
- News & Updates
- Manufacturing
- Social Media
- Veterinary Line
- Analyzers
- QwikChecks
- LIS QwikLink
- Validation Kit
- Vet Products
- Recommendations
- Validation
- Quality Control
- Proficiency
- Technical Bulletins
- Procedure Documents
- User Guides
- MSDS Sheets
- Training Videos
- Service Blog
- Trials / Studies
- Software / Upgrades
- Batch Releases
- Luvv Letters
- Find a Distributor
- Distributor Support

Rapid - Objective - Standardized Semen Analysis Solutions... Remember, it ALL Started with a Sperm!

RSS  Medical Electronic Systems Service and Support Updates

Understanding Liquefaction in Semen Samples

Thursday, November 21, 2013


A semen sample that presents with delayed liquefaction or high viscosity should be reported during the testing process. These are abnormal parameters and are clinically significant because they may indicate a male accessory gland malfunction (Please see two abstracts below). Nevertheless, delayed liquefaction does not necessarily indicate infertility. A post-coital test (PCT) can answer this question (Please see below). There is no direct evidence that the female tract contains enzymes that promote semen liquefaction, but in some cases, motile sperm in non-liquefied specimens can be found when examining cervical mucus after sexual intercourse (Please see below).


What Is It? When semen is ejaculated, it is thick and gelatinous. This is to help it adhere to the cervix. The semen eventually liquefies to enable the sperm to swim better.

What Is Considered Normal? Semen should liquefy within 20 to 30 minutes of ejaculation.

What Might Be Wrong if Results Are Abnormal? Delayed liquefaction may indicate a problem with the prostate, the seminal vesicles, or the bulbourethral glands, which are also known as the male accessory glands. If delayed liquefaction occurs, your doctor may perform a post-coital test (PCT). This fertility test evaluates the woman's cervical mucus after sexual intercourse. If sperm are found and moving normally, then delayed liquefaction is not considered a problem.


The transport of sperm is dependent upon several factors. The sperm must be capable of propelling themselves through the environment of the female vagina and cervix. This environment, which is under cyclic hormonal control, must be favorable to admit the sperm without destroying them. Finally, the sperm must possess the capability of converting to a form that can penetrate the cell membrane of the egg (capacitation).

Following ejaculation, the semen forms a gel which provides protection for the sperm from the acidic environment of the vagina. The gel is liquefied within 20-30 minutes by enzymes from the prostate gland. This liquefaction is important to free the sperm so transportation may occur. The seminal plasma is left in the vagina. The protected sperm with the greatest motility travel through the layers of cervical mucus that guard the entrance to the uterus. During ovulation, this barrier becomes thinner and changes its acidity creating a friendlier environment for the sperm. The cervical mucus acts as a reservoir for extended sperm survival. Once the sperm have entered the uterus, contractions propel the sperm upward into the fallopian tubes. The first sperm enter the tubes minutes after ejaculation. The first sperm, however, are likely not the fertilizing sperm. Motile sperm can survive in the female reproductive tract for up to 5 days.



Direct Link to this Post: Permalink     


Additional Blog Posts:


  1. Technical Release Bulletin: Fixed Coverslip Slides Sperm/Bead Counting Principles Eric Carver 16-Nov-2017
  2. Technical Release Bulletin for QC of Morphology Pre-stained Slides Eric Carver 07-Oct-2017
  3. New SQA-Vision Upgrade | Version 44.3.193 Eric Carver 29-Aug-2017
  4. QwikCheck™ Liquefaction Kit Product Update Eric Carver 24-Aug-2017
  5. How to Utilize the Backup and Restore Feature of the SQA-Vision Eric Carver 14-Aug-2017
  6. 2017 AACC - ASCLS Show in San Diego California Eric Carver 06-Aug-2017
  7. Join MES at the 2017 AACC-ASCLS Exhibit San Diego Eric Carver 20-Jul-2017
  8. ISSRF India - Double Blind Study - Manual vs SQA-Vision Eric Carver 06-Jun-2017
  9. Chymotrypsin vs Hyaluronidase Eric Carver 01-Jun-2017
  10. Ransomware Prevention and Protection on MES Systems Eric Carver 01-Jun-2017
  11. Updated QwikCheck QC Beads Storage Recommendations Eric Carver 28-Apr-2017
  12. Precision Vs Accuracy Example Eric Carver 23-Apr-2017
  13. Xytex Cryo International Letter of Recommendation Eric Carver 31-Mar-2017
  14. Oakland University Letter of Recommendation Eric Carver 15-Mar-2017
  15. No Lubricants During Collection Eric Carver 15-Feb-2017
  16. Side by Side Correlation Eric Carver 15-Feb-2017
  17. Join Medical Electronic Systems at the 2016 AACC and ASCLS Clinical Lab Expo Eric Carver 28-Jun-2016
  18. Baptist Medical Center South SQA-V Automated Sperm Quality Analyzer Recommendation Eric Carver 28-Jun-2016
  19. The Importance of Semen Sample Liquefaction and Viscosity for Semen Analysis Eric Carver 16-Jun-2016
  20. SQA Automated Semen Analyzer Letter of Recommendation from HSHS St. Joseph's Highland Hospital Eric Carver 09-Jun-2016
  21. Minimum Sample Volume Requirements for SQA Systems and Dilution Options Eric Carver 28-May-2016
  22. Jackson Madison County Letter of Recommendation Eric Carver 26-May-2016
  23. Adena Regional Medical Center SQA-V Semen Analysis Letter of Recommendation Eric Carver 25-May-2016
  24. MISES A JOUR Automation Study | In French Eric Carver 05-May-2016
  25. 2016 CAP Proficiency Instructions for SQA Systems Eric Carver 27-Apr-2016
  26. Medical Electronic Systems SQA-VISION Development Validation Eric Carver 22-Apr-2016
  27. SQA-VISION Training Outline Now Available Eric Carver 31-Mar-2016
  28. SQA-VISION Training Outline Now Available Eric Carver 31-Mar-2016
  29. What is the clinical relevance of distinguishing spermatids from WBCs during a semen analysis? Eric Carver 29-Feb-2016
  30. Health Canada Approval for Medical Electronic Systems Eric Carver 27-Oct-2015
  31. 2015 CAMLT in Sacramento | California Eric Carver 01-Oct-2015
  32. 2015 AACC | ASCLS Annual Conference | Atlanta GA Eric Carver 01-Sep-2015
  33. Temperature Controls for Storing QwikCheck Dilution Kits After Opening Eric Carver 24-Aug-2015
  34. QwikCheck Semen Test Strips vs. Combur Urine Test Strips for WBC Assessment in Semen Eric Carver 18-Aug-2015
  35. Inter and Intra Device Study | QAP semen analysis results using the SQA-V GOLD Eric Carver 16-Aug-2015
  36. How the SQA-V System Calculates Sperm Per Scan on Post Vas Mode Eric Carver 05-Aug-2015
  37. Clinical Validation Limits in Semen Analysis | CAP | CLIA Eric Carver 03-Aug-2015
  38. MSDS | SDS Sheets for ALL MES Products Eric Carver 29-Apr-2015
  39. Routine Calibration Confirmation | Printing the Self Test Data Eric Carver 13-Apr-2015
  40. Printing the SELF TEST Data for Calibration Confirmation of any customer system Eric Carver 13-Apr-2015
  41. Thank you to our distributors Eric Carver 24-Mar-2015
  42. Technical Bulletin Update | QwikCheck Test Strips QC Eric Carver 02-Feb-2015
  43. General Fort Leonard Wood Letter of Recommendation | SQA Semen Analyzer Eric Carver 30-Jan-2015
  44. Stabilized Sperm Proficiency Challenge for LOW LEVEL Target Values Eric Carver 29-Oct-2014
  45. Eastern Idaho Regional Medical Center Letter of Recommendation Eric Carver 23-Oct-2014
  46. Importing the SQA-V Archive into V-Sperm Eric Carver 14-Oct-2014
  47. SQA-V Cleaning Procedure Update | Daily and Weekly Maintenance Eric Carver 07-Oct-2014
  48. Changing the SQA-V Gold Printer Ribbon | Training Video Eric Carver 01-Oct-2014
  49. Arabians LTD Recommendation Video for Horse Analyzer Eric Carver 30-Sep-2014
  50. Using the SQA-V and V-Sperm Visualization System Eric Carver 30-Sep-2014
  51. V-Sperm Gold PC Computer Minimum Requirements Overview | Click Image Eric Carver 22-Sep-2014
  52. Semen Analysis in Urine | Retrograde Ejaculation Eric Carver 15-Sep-2014
  53. MSDS Material Safety Data Sheet Updates for all MES Products Eric Carver 21-Aug-2014
  54. QwikCheck Gold BULL Training Video Eric Carver 20-Aug-2014
  55. Technical Bulletin Update | SQA-V Accessory Storage Conditions Eric Carver 20-Aug-2014
  56. New Daily Maintenence Checklist Now Available for SQA Platforms Eric Carver 19-Aug-2014
  57. 2014 ASCLS-Hawaii Clinical Laboratory Symposium Eric Carver 14-Aug-2014
  58. AUSTRALIA | SQA-V Gold Automated Sperm Quality Analyzer Placements Eric Carver 21-Jul-2014
  59. 2014 California Association for Medical Laboratory Technology Annual Meeting Eric Carver 17-Jul-2014
  60. NEW SQA and QwikCheck Cleaning Instructions | Effective May 2014 Eric Carver 31-May-2014
  61. NEW SQA and QwikCheck Cleaning Instructions | Effective May 2014 Eric Carver 31-May-2014
  62. SQA-V Service Manual Update | WHO 3rd 4th 5th Edition Eric Carver 01-May-2014
  63. SQA-V Concentration Standard Explained Eric Carver 25-Apr-2014
  64. WHO 5th Edition Manual STRICT Morphology Training and Testing Eric Carver 22-Apr-2014
  65. WHO Recommendations for Manual Sperm Concentration Analysis Eric Carver 22-Apr-2014
  66. Join MES at the 2014 AACC | ASCLS Show in Chicago Eric Carver 22-Apr-2014
  67. Reason for Assessing WBC Levels on the SQA-V Eric Carver 06-Feb-2014
  68. Automated Semen Analysis in 3 Minutes Start to Finish Eric Carver 30-Jan-2014
  69. SQA-V Visualization Counting Instructions - WHO 5th Edition Eric Carver 26-Jan-2014
  70. QwikCheck Test Strip Color Interpretation Eric Carver 23-Jan-2014
  71. Post Vasectomy Testing on the SQA-V - Work Flow Recommendation Eric Carver 23-Jan-2014
  72. Comparison of WHO 4th and 5th Edition Morphology Criteria Eric Carver 23-Jan-2014
  73. Welcome to the MES Global Distributor Support Center Eric Carver 23-Jan-2014
  74. Mother Board Optical Block Replacement Kit Video Eric Carver 23-Jan-2014
  75. Troubleshooting Blank Operation Screen Eric Carver 22-Jan-2014
  76. Cleaning the SQA-V Gold - Daily Maintenance Eric Carver 22-Jan-2014
  77. Troubleshooting Blank Operation Screen Eric Carver 22-Jan-2014
  78. Changing the SQA-V Paper Paper Eric Carver 21-Jan-2014
  79. Changing the SQA-V Paper Paper Eric Carver 21-Jan-2014
  80. By popular demand MES is now selling our Sperm T-Shirts Eric Carver 18-Dec-2013
  81. Understanding Liquefaction in Semen Samples Eric Carver 21-Nov-2013
  82. Journal of Assisted Reproduction and Genetics SQA-V Comparison Study Eric Carver 21-Nov-2013
  83. Testing PH and WBCs Before Sample Treatment or Dilution Eric Carver 05-Nov-2013
  84. Join MES at the 2013 AAEP Convention in Nashville Eric Carver 29-Oct-2013
  85. Manufacturers Recommended Semi-Annual Calibration Confirmation Eric Carver 25-Oct-2013
  86. Ariela Arabians Letter of Recommendation Eric Carver 29-Aug-2013
  87. Medisoos Letter of Recommendation Eric Carver 29-Aug-2013
  88. Room Temperature on the SQA-V - Defined Eric Carver 25-Jul-2013
  89. Semen Sample Collection - WHO 5th Edition Recommendations Eric Carver 18-Jul-2013
  90. AACC and ASCLS Show in Houston TX - Join MES at Booth 2704 Eric Carver 17-Jul-2013
  91. The Influence of Red Blood Cells on the SQA-V Sperm Quality Analyzer Eric Carver 19-Jun-2013
  92. Equine Semen Analysis - QwikCheck Gold Sperm Quality Analyzer for Horses at Arabians Ltd. Eric Carver 22-May-2013
  93. Amethyst Acres - Beta Trial Site for Semen Analyzer Eric Carver 15-May-2013
  94. Walker Baptist Medical Center Recommendation | Jasper AL Eric Carver 01-May-2013
  95. Twin Embryo Extraction from a Mare Eric Carver 30-Apr-2013
  96. The Pathology Lab SQA-V Gold Recommendation | Lake Charles LA Eric Carver 30-Apr-2013
  97. Sample Mixing for Semen Analysis - WHO 5th Edition 2.4.1 (Pages 17 and 18) Eric Carver 01-Mar-2013
  98. QwikCheck™ Beads Compliance with WHO 3rd, 5th and 5th Edition Manuals Eric Carver 12-Feb-2013
  99. Automated Semen Analysis - The End of Manual Analysis? Eric Carver 10-Dec-2012
  100. Treating Highly Viscous Samples in Compliance with WHO 5th Eric Carver 26-Nov-2012


Search Tags (Alphabetical):